Coordination of mA mRNA Methylation and Gene Transcription by ZFP217 Regulates Pluripotency and Reprogramming

Bhaskar Chanda Stem Cell Aguillo et al. show that ZFP217 coordinates epigenetic and epitranscriptomic networks to control embryonic stem cell pluripotency and somatic cell reprogramming. ZFP217 directly activates core stem cell genes and restrains m6A deposition in their transcripts through interaction with METTL3, coupling transcription and mRNA methylation to control stemness.

from Cell Stem Cell http://ift.tt/20d9YNs
via Bhaskar Chanda UHN

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