Targeted Application of Human Genetic Variation Can Improve Red Blood Cell Production from Stem Cells

Bhaskar Chanda Stem Cell Through population analysis, Giani et al. show that rare mutations in SH2B3 associate with increased hemoglobin levels in humans. Applying this insight, they suppress SH2B3 in hematopoietic stem/progenitor cells and use CRISPR/Cas9 genome editing to inactivate it in embryonic stem cells to improve mature erythroid cell yield following differentiation.

from Cell Stem Cell
via Bhaskar Chanda UHN


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