Regeneration of Thyroid Function by Transplantation of Differentiated Pluripotent Stem Cells

Bhaskar Chanda Stem Cell The molecular pathways governing thyroid differentiation are poorly understood. Kurmann et al. show that BMP4 and FGF2 activate key pathways that drive thyroid specification in vivo and in vitro, enabling differentiation of mouse and human pluripotent stem cells into thyroid follicular cells that produce thyroid hormones and rescue mouse hypothyroidism.

from Cell Stem Cell
via Bhaskar Chanda UHN


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