Leukemia-Associated Cohesin Mutants Dominantly Enforce Stem Cell Programs and Impair Human Hematopoietic Progenitor Differentiation

Bhaskar Chanda Stem Cell Mazumdar et al. investigate the effects of leukemia-associated cohesin complex mutations on human hematopoietic stem and progenitor cells. Cohesin mutants are found to impair differentiation and enforce stem cell programs through the modulation of ERG, GATA2, and RUNX1 chromatin accessibility, expression, and activity, suggesting a mechanism contributing to leukemogenesis.

from Cell Stem Cell http://ift.tt/1MGtQij
via Bhaskar Chanda UHN


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