Frequent Somatic Mutation in Adult Intestinal Stem Cells Drives Neoplasia and Genetic Mosaicism during Aging

Bhaskar Chanda Stem Cell Bardin and colleagues show that aging Drosophila intestinal stem cells (ISCs) acquire frequent spontaneous mutations, including frequent loss of heterozygosity arising from homologous mitotic recombination that results in clonal mosaicism. They also show spontaneous gene deletions and chromosomal rearrangements in aging ISCs, which can promote neoplasia formation through inactivating Notch.

from Cell Stem Cell
via Bhaskar Chanda UHN


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