Small Molecules Efficiently Reprogram Human Astroglial Cells into Functional Neurons

Bhaskar Chanda Stem Cell In this study, Chen and colleagues demonstrate chemical reprogramming of human astrocytes into functional neurons with a cocktail of small molecules. This chemical reprogramming is mediated through epigenetic silencing of glial genes and transcriptional activation of neural transcription factors such as NeuroD1 and Neurogenin 2.

from Cell Stem Cell
via Bhaskar Chanda UHN


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