Hematopoietic Differentiation Is Required for Initiation of Acute Myeloid Leukemia

Bhaskar Chanda Stem Cell Ye et al. show that myeloid differentiation is required for acquiring a leukemia stem cell (LSC) phenotype and AML initiation and that blocking GMP formation abrogates leukemic transformation. Cytokine-induced bypass of this block restores LSC and AML development, with GMPs providing a genomic environment permissive for activating LSC transcriptional programs.

from Cell Stem Cell http://ift.tt/1LQ592u
via Bhaskar Chanda UHN


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