Extensive Nuclear Reprogramming Underlies Lineage Conversion into Functional Trophoblast Stem-like Cells

Bhaskar Chanda Stem Cell Induced pluripotency is accompanied by extensive nuclear reprogramming, which is often incomplete during direct interlineage cell conversion. Here, we show overexpression of Gata3, Eomes, and Tfap2c enables a high degree of nuclear reprogramming, independently of pluripotency, and converts mouse fibroblasts into functional induced trophoblast stem-like cells (iTSCs).

from Cell Stem Cell http://ift.tt/1LQ58vk
via Bhaskar Chanda UHN

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