Direct Induction of Trophoblast Stem Cells from Murine Fibroblasts

Bhaskar Chanda Stem Cell Kubaczka et al. report that transient expression of Tfap2c, Gata3, Eomes, and Ets2 can reprogram murine fibroblasts into induced trophoblast stem cells (iTSCs). iTSCs are fully functional and exhibit full demethylation of key loci, showing that the lineage barrier between somatic and extra-embryonic cell fates can be overcome.

from Cell Stem Cell
via Bhaskar Chanda UHN


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