HDAC8 Inhibition Specifically Targets Inv(16) Acute Myeloid Leukemic Stem Cells by Restoring p53 Acetylation

Bhaskar Chanda Stem Cell Qi et al. demonstrate that the inv(16) fusion protein interacts with the tumor suppressor p53 and HDAC8, thereby causing aberrant HDAC8-mediated deacetylation and inactivation of p53. HDAC8 deletion or inhibition selectively depletes LSC activity by reactivating p53, highlighting HDAC8 as an effective therapeutic target to specifically eliminate inv(16) AML LSCs.

from Cell Stem Cell http://ift.tt/1KjeRwm
via Bhaskar Chanda UHN


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