ELABELA Is an Endogenous Growth Factor that Sustains hESC Self-Renewal via the PI3K/AKT Pathway

Bhaskar Chanda Stem Cell Ho et al. show that ELA is an endogenous peptide hormone produced by human embryonic stem cells that supports self-renewal through auto/paracrine activation of PI3K/AKT signaling. ELA promotes cell-cycle progression and protein translation, prevents apoptosis upon cellular stress, and primes hESCs for endodermal differentiation via activation of TGFβ signaling.

from Cell Stem Cell http://ift.tt/1KjeQbF
via Bhaskar Chanda UHN


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