CD93 Marks a Non-Quiescent Human Leukemia Stem Cell Population and Is Required for Development of MLL-Rearranged Acute Myeloid Leukemia

Bhaskar Chanda Stem Cell Iwasaki et al. demonstrate that leukemia stem cells (LSCs) in a distinctive genetic subtype of leukemia are non-quiescent. Although human LSCs are typically enriched in the highly quiescent CD34+CD38− phenotypic compartment, co-expression of the lectin CD93 further demarcates LSCs as a discrete subpopulation of actively cycling, non-quiescent AML cells.

from Cell Stem Cell http://ift.tt/1iS9hrA
via Bhaskar Chanda UHN

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