Genome-wide RNA-Seq of Human Motor Neurons Implicates Selective ER Stress Activation in Spinal Muscular Atrophy

Bhaskar Chanda Stem Cell Loss of the protein SMN causes spinal muscular atrophy, but it is unclear why deficiency in the ubiquitously expressed protein primarily affects motor neurons. In this study, Ng et al. show that a hyperactive ER stress pathway in SMA motor neurons could explain this selective neuronal vulnerability.

from Cell Stem Cell
via Bhaskar Chanda UHN


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