Aberrant Lipid Metabolism in the Forebrain Niche Suppresses Adult Neural Stem Cell Proliferation in an Animal Model of Alzheimer’s Disease

Bhaskar Chanda Stem Cell Hamilton et al. identify deregulation of niche fatty acid metabolism as a mechanism of disease-induced stem cell impairment. They show that interfering with oleic acid signaling or synthesis rescues NSC proliferation in a mouse model of Alzheimer’s, revealing a potential approach to promote NSC-mediated brain function and repair.

from Cell Stem Cell http://ift.tt/1hhEa7G
via Bhaskar Chanda UHN


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