Humanized Mice Reveal Differential Immunogenicity of Cells Derived from Autologous Induced Pluripotent Stem Cells

Bhaskar Chanda Stem Cell Patient iPSCs have potential as a renewable source for autologous cell therapy that avoids immune rejection. Using a humanized mouse model with a functional human immune system, Zhao et al. observe differential immune responses to various autologous hiPSC derivatives, including rejection of smooth muscle cells and tolerance to retinal pigmented epithelium.

from Cell Stem Cell
via Bhaskar Chanda UHN


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