Human Neuropsychiatric Disease Modeling using Conditional Deletion Reveals Synaptic Transmission Defects Caused By Heterozygous Mutations in

Bhaskar Chanda Stem Cell Pak et al. show that introduction of a conditional mutation in a schizophrenia- and autism-associated gene enables precise functional analysis of neurons with a carefully controlled genetic background. Using this approach, they uncover haploinsufficiency phenotypes for human NRXN1, mimicking mutations seen in a range of neuropsychiatric disorders including schizophrenia.

from Cell Stem Cell
via Bhaskar Chanda UHN


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