A TIM-3/Gal-9 Autocrine Stimulatory Loop Drives Self-Renewal of Human Myeloid Leukemia Stem Cells and Leukemic Progression

Bhaskar Chanda Stem Cell Signaling mechanisms specifically active in leukemic stem cells (LSCs) provide therapeutic opportunities. Akashi and colleagues identify a TIM-3/Gal-9 autocrine stimulatory loop that regulates self-renewal of human LSCs, through co-activation of NF-κB and β-catenin signaling, and promotes leukemic progression in a range of myeloid malignancies.

from Cell Stem Cell http://ift.tt/1L8MOCH
via Bhaskar Chanda UHN


Tags: , , , , , , ,

Leave a Reply

Fill in your details below or click an icon to log in:

WordPress.com Logo

You are commenting using your WordPress.com account. Log Out / Change )

Twitter picture

You are commenting using your Twitter account. Log Out / Change )

Facebook photo

You are commenting using your Facebook account. Log Out / Change )

Google+ photo

You are commenting using your Google+ account. Log Out / Change )

Connecting to %s

%d bloggers like this: