A TIM-3/Gal-9 Autocrine Stimulatory Loop Drives Self-Renewal of Human Myeloid Leukemia Stem Cells and Leukemic Progression

Bhaskar Chanda Stem Cell Signaling mechanisms specifically active in leukemic stem cells (LSCs) provide therapeutic opportunities. Akashi and colleagues identify a TIM-3/Gal-9 autocrine stimulatory loop that regulates self-renewal of human LSCs, through co-activation of NF-κB and β-catenin signaling, and promotes leukemic progression in a range of myeloid malignancies.

from Cell Stem Cell http://ift.tt/1L8MOCH
via Bhaskar Chanda UHN

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