Ground State Conditions Induce Rapid Reorganization of Core Pluripotency Factor Binding before Global Epigenetic Reprogramming

Bhaskar Chanda Stem Cell Meissner and colleagues provide a comprehensive characterization of the early OCT4, SOX2, and NANOG binding dynamics during the transition from serum/LIF to 2i. The target rewiring predominantly affects distal regulatory elements with a plausible link to the upstream signaling pathways. Notably, these events appear before any major epigenetic reprogramming events, which occur only later in the transition.

from Cell Stem Cell
via Bhaskar Chanda UHN


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