Ground State Conditions Induce Rapid Reorganization of Core Pluripotency Factor Binding before Global Epigenetic Reprogramming

Bhaskar Chanda Stem Cell Meissner and colleagues provide a comprehensive characterization of the early OCT4, SOX2, and NANOG binding dynamics during the transition from serum/LIF to 2i. The target rewiring predominantly affects distal regulatory elements with a plausible link to the upstream signaling pathways. Notably, these events appear before any major epigenetic reprogramming events, which occur only later in the transition.

from Cell Stem Cell http://ift.tt/1INRNZ5
via Bhaskar Chanda UHN

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