Tetraspanin 3 Is Required for the Development and Propagation of Acute Myelogenous Leukemia

Bhaskar Chanda Stem Cell Reya and colleagues identify Tetraspanin 3 as a key signal required for AML. Tspan3 deletion leads to improved survival in mouse models of AML and reduced cancer growth in xenografts. Tspan3 loss impairs migration of leukemic cells to SDF suggesting that it may influence oncogenesis by controlling a normal chemokine response.

from Cell Stem Cell http://ift.tt/1TTQJV2
via Bhaskar Chanda UHN


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