Robust In Vitro Induction of Human Germ Cell Fate from Pluripotent Stem Cells

Bhaskar Chanda Stem Cell Saitou and colleagues report induction of human primordial germ cell-like cells (hPGCLCs) from pluripotent stem cells. hPGCLC and mouse PGC specification rely on similar signaling pathways but utilize distinct transcriptional programs, highlighting differences in PGC induction and demonstrating the utility of hPGCLCs for studying human germ cell development in vitro.

from Cell Stem Cell
via Bhaskar Chanda UHN


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