Aspp1 Preserves Hematopoietic Stem Cell Pool Integrity and Prevents Malignant Transformation

Bhaskar Chanda Stem Cell Suda and colleagues show that the hematopoietic stem cell (HSC) pool integrity is coordinately controlled by p53 and its proapoptotic activator Aspp1. Aspp1 has both p53-dependent and -independent functions in regulating HSC self-renewal and DNA damage tolerance, and concomitant deletion of Aspp1 and p53 in HSCs leads to hematological malignancies.

from Cell Stem Cell
via Bhaskar Chanda UHN


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