Functionally Distinct Subsets of Lineage-Biased Multipotent Progenitors Control Blood Production in Normal and Regenerative Conditions

Bhaskar Chanda Stem Cell Pietras et al. show that HSCs produce functionally distinct lineage-biased MPPs that work together to adapt blood production to hematopoietic demands. Two rare subsets of myeloid-biased MPPs are important for maintaining blood homeostasis at steady state and serve as a potent source of myeloid amplification in regenerative conditions.

from Cell Stem Cell
via Bhaskar Chanda UHN


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