An RNA-Containing Negative Feedback Loop Regulates p53-Mediated Apoptosis in Embryonic Stem Cells

Bhaskar Chanda Stem Cell Li et al. show that an ESC-enriched regulatory RNA, Apela, positively regulates p53-mediated DNA damage-induced apoptosis (DIA) of ESCs. Apela, hnRNPL, and p53 form a tri-element negative feedback loop that may help ESCs navigate the balance between maintaining inactive p53 under baseline conditions and eliciting DIA upon DNA damage.

from Cell Stem Cell http://ift.tt/1JbYEr0
via Bhaskar Chanda UHN

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