An RNA-Containing Negative Feedback Loop Regulates p53-Mediated Apoptosis in Embryonic Stem Cells

Bhaskar Chanda Stem Cell Li et al. show that an ESC-enriched regulatory RNA, Apela, positively regulates p53-mediated DNA damage-induced apoptosis (DIA) of ESCs. Apela, hnRNPL, and p53 form a tri-element negative feedback loop that may help ESCs navigate the balance between maintaining inactive p53 under baseline conditions and eliciting DIA upon DNA damage.

from Cell Stem Cell
via Bhaskar Chanda UHN


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