β-Catenin Regulates Primitive Streak Induction through Collaborative Interactions with SMAD2/SMAD3 and OCT4

Bhaskar Chanda Stem Cell In this article, Funa, Schachter, and colleagues et al. provide mechanistic insights into how Wnt signaling controls early cell lineage decisions. β-catenin occupies regulatory regions in numerous PS and neural crest genes, and direct interactions between β-catenin and SMAD2/SMAD3 in proximity to OCT4 binding are required to specifically activate PS genes.

from Cell Stem Cell http://ift.tt/1GbgCXx
via Bhaskar Chanda UHN

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