Opposing Roles for the lncRNA and Its Genomic Locus in Regulating Gene Activation during Embryonic Stem Cell Differentiation

Bhaskar Chanda Stem Cell Dissection of the precise contribution of RNA transcripts versus genomic DNA sequences is important for functional assessment of long noncoding RNAs. Here, Shen and colleagues demonstrate discrete and opposing roles for the lncRNA transcript Haunt and its genomic locus in regulating the HOXA gene cluster during embryonic stem cell differentiation.

from Cell Stem Cell http://ift.tt/1PSUjxL
via Bhaskar Chanda UHN

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