The Long Noncoding RNA Regulates Neuronal Differentiation of Embryonic and Postnatal Neural Stem Cells
Bhaskar Chanda Stem Cell Ramos et al. describe Pinky (Pnky), a neural-specific lncRNA that localizes to the nucleus of neural stem cells (NSCs). Pnky knockdown in NSCs increases neurogenesis. Pnky interacts with splicing regulator PTBP1, and PTBP1 and Pnky regulate the expression and splicing of a core set of transcripts related to neuronal differentiation.