Lymphoid Regeneration from Gene-Corrected SCID-X1 Subject-Derived iPSCs

Bhaskar Chanda Stem Cell Menon, Firth, and colleagues show that TALEN-mediated correction of a novel splice site mutation in the IL-2Rγ gene rescues defective development of mature NK cells from iPSCs derived from a SCID-X1 subject. They demonstrate correction of the aberrant splicing of the IL-2Rγ in T cell precursors.

from Cell Stem Cell
via Bhaskar Chanda UHN


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