Elucidating Molecular Phenotypes Caused by the SORL1 Alzheimer’s Disease Genetic Risk Factor Using Human Induced Pluripotent Stem Cells

Bhaskar Chanda Stem Cell Development of late-onset, sporadic Alzheimer’s disease (SAD) has been linked with a range of genetic loci, but determining how variants within these loci contribute to disease progression remains challenging. Using hIPSC-derived neurons from SAD patients and controls, Young et al. link risk and protective variants in the SORL1 gene, an SAD-associated locus, with BDNF-sensitive SORL1 expression, APP processing, and control of amyloid β production.

from Cell Stem Cell http://ift.tt/1NP0RMJ
via Bhaskar Chanda UHN


Tags: , , , , , , ,

Leave a Reply

Fill in your details below or click an icon to log in:

WordPress.com Logo

You are commenting using your WordPress.com account. Log Out / Change )

Twitter picture

You are commenting using your Twitter account. Log Out / Change )

Facebook photo

You are commenting using your Facebook account. Log Out / Change )

Google+ photo

You are commenting using your Google+ account. Log Out / Change )

Connecting to %s

%d bloggers like this: