Successful Function of Autologous iPSC-Derived Dopamine Neurons following Transplantation in a Non-Human Primate Model of Parkinson’s Disease
Bhaskar Chanda Stem Cell A pre-clinical test of transplantation of autologous iPSC-derived dopamine neurons in a cynomolgus monkey model of Parkinson’s disease provides proof of principle for long-term innervation and functional benefit without a requirement for immunosuppression.
Bhaskar Chanda Stem Cell The hematopoietic stem cell (HSC) compartment is heterogeneous in terms of cell cycle properties. Laurenti et al. show that the timing of exit from quiescence in human HSC subsets is controlled by CDK6 expression levels. This differential control has an impact on the long-term preservation of the HSC pool.
Bhaskar Chanda Stem Cell Zhou and colleagues show that formation of m6A on mRNAs is regulated by miRNAs via a sequence pairing mechanism, and that in addition to differential distribution in pluripotent and differentiated cells, m6A has a positive influence on reprogramming to pluripotency.