The NAD-Dependent SIRT1 Deacetylase Translates a Metabolic Switch into Regulatory Epigenetics in Skeletal Muscle Stem Cells

Bhaskar Chanda Stem Cell Connecting metabolic cues to stem cell activity via epigenetic regulation: Sartorelli and colleagues show that during activation, satellite cells undergo a metabolic switch that leads to decreased intracellular NAD+, reduced SIRT1 deacetylase activity, elevated H4K16 acetylation, and an increase in muscle-related gene expression.

from Cell Stem Cell
via Bhaskar Chanda UHN


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