Bhaskar Chanda Stem Cell The Wnt signaling pathway controls stem cell identity in the intestinal epithelium, but it has remained unclear how the continuous Wnt gradient is translated into discrete cell type specification. Schuijers et al. show that the transcription factor Ascl2 forms a bimodal switch that interprets Wnt levels and specifies stem cells.
The NAD-Dependent SIRT1 Deacetylase Translates a Metabolic Switch into Regulatory Epigenetics in Skeletal Muscle Stem Cells
Bhaskar Chanda Stem Cell Connecting metabolic cues to stem cell activity via epigenetic regulation: Sartorelli and colleagues show that during activation, satellite cells undergo a metabolic switch that leads to decreased intracellular NAD+, reduced SIRT1 deacetylase activity, elevated H4K16 acetylation, and an increase in muscle-related gene expression.