Archive | January 2015

Ascl2 Acts as an R-spondin/Wnt-Responsive Switch to Control Stemness in Intestinal Crypts

Bhaskar Chanda Stem Cell The Wnt signaling pathway controls stem cell identity in the intestinal epithelium, but it has remained unclear how the continuous Wnt gradient is translated into discrete cell type specification. Schuijers et al. show that the transcription factor Ascl2 forms a bimodal switch that interprets Wnt levels and specifies stem cells.

from Cell Stem Cell http://ift.tt/1BLvI90
via Bhaskar Chanda UHN

The NAD-Dependent SIRT1 Deacetylase Translates a Metabolic Switch into Regulatory Epigenetics in Skeletal Muscle Stem Cells

Bhaskar Chanda Stem Cell Connecting metabolic cues to stem cell activity via epigenetic regulation: Sartorelli and colleagues show that during activation, satellite cells undergo a metabolic switch that leads to decreased intracellular NAD+, reduced SIRT1 deacetylase activity, elevated H4K16 acetylation, and an increase in muscle-related gene expression.

from Cell Stem Cell http://ift.tt/1E4s0VT
via Bhaskar Chanda UHN