Tolerance Induction and Reversal of Diabetes in Mice Transplanted with Human Embryonic-Stem-Cell-Derived Pancreatic Endoderm

Bhaskar Chanda Stem Cell Szot et al. demonstrate that targeting T cell costimulatory pathways prevents rejection of xenogeneic human embryonic-stem-cell-derived pancreatic endoderm (hESC-PE) in mice and allogeneic hESC-PE in humanized mice. The approach enabled grafts to develop into islet-like structures capable of producing human insulin and maintaining normal blood glucose levels.

from Cell Stem Cell http://ift.tt/1z8PfyV
via Bhaskar Chanda UHN

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