Perivascular Gli1 Progenitors Are Key Contributors to Injury-Induced Organ Fibrosis

Bhaskar Chanda Stem Cell The cellular origins of fibrosis in different tissues are unclear. Kramann et al. show that Gli1 marks a network of perivascular mesenchymal-stem-cell-like cells that generate myofibroblasts and play a central role in organ fibrosis after injury, and ablating these cells ameliorates fibrosis and rescues organ function.

from Cell Stem Cell
via Bhaskar Chanda UHN


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